Biodegradable Mg-based alloys for orthopedic implants
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Project Details
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Design, production and testing of biodegradable alloys from Mg-Ca-Zr, Mg-Ca-Y, Mg-Ca-Mn, Mg-Ca-Gd systems with applications in medical implantology. Also the project include in vitro and in vivo biocompatibility testing in animal models for the classification of alloys used as biodegradable materials usable in medical implantology.
Project Coordinator
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Specific objectives:
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- Design, production and testing of biodegradable alloys from Mg-Ca-Zr, Mg-Ca-Y, Mg-Ca-Mn, Mg-Ca-Gd systems with applications in medical implantology;
- Employing 3 young researchers with full time (TUIASI, USAMV si INCDFT-IFT IAȘI);
- In vitro and in vivo biocompatibility testing in animal models for the classification of alloys used as biodegradable materials usable in medical implantology;
- Support the technological transfer of the results obtained at regional and national level to the economic and medical environment in Romania;
- Identifying an optimal, complex formula, made up of all six elements, as an ideal material for orthopedic implants.
Results
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- Designing, obtaining and testing 4 classes of biodegradable materials: Mg-Ca-Zr, Mg-Ca-Y, Mg-Ca-Mn, Mg-Ca-Gd, with 5 different concentrations;
- Determination of microstructural, mechanical, electrochemical, in vitro and in vivo properties of biodegradable alloys;
- Identifying an optimal concentration with specific concentration for medical applications in orthopedics;
- Dissemination of results through participation in national and international conferences;
- Publication of at least 6 ISI / BDI scientific articles and 4 patent applications patent applications;
- Organization of internships with students, master students, PhD students at specialized companies;
- Organization of meetings with economic agents / partners for the preparation of technological transfer to industrial beneficiaries.
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